What is Wegovy® (Semaglutide)?

Wegovy® is a prescription-only medicine used to support long-term weight management in adults who are living with obesity, or who are overweight and have weight-related health conditions. It is not a cosmetic or short-term solution, but a clinically approved treatment designed to help people manage their weight safely over time.

Wegovy® contains semaglutide, a medicine that mimics a naturally occurring hormone involved in appetite regulation. It is taken as a once-weekly injection and is only supplied following a medical assessment and approval by a qualified prescriber.

 

What Wegovy Is and How It Works
Wegovy® works by acting on areas of the brain that regulate appetite and food intake. By slowing how quickly the stomach empties and increasing feelings of fullness after eating, it can help reduce hunger and support lower calorie intake. Many people find that this makes it easier to follow healthier eating habits and maintain long-term changes.

Wegovy® is intended to be used alongside lifestyle changes, including dietary adjustments and increased physical activity. It is not a replacement for these changes, but a medical tool that can support them when weight has been difficult to manage through lifestyle measures alone.

Am I eligible?

Wegovy® is a prescription only medication, not personal preference. It may be suitable for adults with a body mass index (BMI) of 30 or above, or for adults with a BMI of 27 or above who also have a weight-related health condition such as high blood pressure, abnormal cholesterol levels, or type 2 diabetes.

Eligibility is assessed through a medical consultation, which looks at your health history, current medications, previous weight-loss attempts, and overall suitability for treatment. Meeting BMI criteria alone does not guarantee that Wegovy® will be prescribed, as safety and clinical appropriateness must always come first.

Am I eligible to Wegovy

 

How Wegovy® Is Taken?

Wegovy® is taken once a week as a small injection under the skin, usually in the abdomen, thigh, or upper arm. Treatment starts at a low dose and is gradually increased over several weeks. This gradual dose increase is important, as it helps the body adjust and reduces the likelihood of side effects.

Most people work up to a maintenance dose over time, although dose adjustments may be made depending on how well the medication is tolerated and how each individual responds. Your prescriber will guide you through this process and review progress during treatment.

Your Wegovy® treatment starts at a low dose to help your body adjust, with gradual increases every four weeks until you reach the maintenance dose.

Wegovy dosage


This schedule is a general guide. Your exact progression will depend on your response to treatment, any side effects, and your prescriber’s clinical judgement. Your clinician may adjust, delay, or reduce your dose if needed to ensure safe and comfortable progress.

 

Can you start on a higher dose?

We recommend that you start on a dose of 0.25mg. This ensures less side effects and allows you to slowly adjust to any such side effects that could occur. Starting on a lower dose and slowly increasing your dose will ensure that you have fewer side effects and interruptions. Wegovy® requires 4 to 5 weeks to stablise in your bloodsteam. Therefore starting on a dose of 0.25mg ensures that your build-up happens safely. 

Expected Weight Loss and What to Realistically Expect?

1 out of 3 patients achieved ≥25% weight loss*

Clinical studies have shown that Wegovy can lead to significant average weight loss when used as prescribed and combined with lifestyle changes. Many people experience steady, gradual weight loss over several months rather than rapid changes.

Results vary between individuals. Some people lose more weight than others, and not everyone responds in the same way. Wegovy® does not guarantee weight loss, and continued use is usually needed to maintain results. Stopping treatment can lead to weight regain, which is why Wegovy® is considered a long-term treatment option rather than a short-term fix. 

Dream Weight Loss Calculator 

BMI DREAM CALCULATOR

 

*Wegovy® 7.2 mg N=1005; placebo N=201.3

Mean baseline body weight Wegovy® 7.2 mg = 112.4 kg, mean baseline body weight placebo = 112.4 kg.

Based on the STEP UP trial: 18.7% (~19%) weight loss with Wegovy® for the treatment policy estimand; 20.7% (~21%) weight loss with Wegovy®

for the trial product estimand (effect in all participants treated as intended).

Wegovy® Side Effects (Semaglutide). What to Expect

Like all prescription weight-loss treatments, Wegovy® (semaglutide) can cause side effects. Many people experience mild, temporary symptoms as the body adjusts, especially during dose increases. If any side effect feels severe, worrying, or does not improve, you should speak to a qualified clinician.

 

Common side effects:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Stomach (abdomen) pain
  • Headache
  • Tiredness (fatigue)
  • Upset stomach
  • Dizziness
  • Feeling bloated
  • Belching
  • Low blood sugar in people with type 2 diabetes
  • Gas
  • Stomach flu
  • Heartburn
  • Runny nose or sore throat

 

Serious side effects, when to seek urgent help:


Stop and seek urgent medical advice if you develop symptoms that may suggest a serious reaction. This includes severe and persistent abdominal pain (which may indicate pancreatitis), signs of gallbladder problems (such as upper abdominal pain, fever, jaundice, or pale stools), or symptoms of a serious allergic reaction (swelling of the face/lips/tongue/throat, breathing or swallowing problems, severe rash or itching, fainting, dizziness, or a very rapid heartbeat). Wegovy may also be linked to kidney problems from dehydration if vomiting or diarrhoea persists, changes in vision in people with type 2 diabetes, increased heart rate, and new or worsening depression or suicidal thoughts.

 

Surgery and anaesthetic reminder:


Because Wegovy® can affect stomach emptying, it may increase the chance of food or liquid entering the lungs during procedures involving anaesthesia or deep sedation. Always tell your surgeon, anaesthetist, or clinic team that you are taking Wegovy® before any procedure.

 

Learn more about Managing Common GLP1 Side Effects

LEARN MORE ABOUT GLP1 SYMPTOMS

Who should not take Wegovy®?

Wegovy® is not appropriate for everyone. Do not use this medication if any of the following apply to you:

You are under 18 years old
You are pregnant, breastfeeding, or planning a pregnancy
You have an allergy to semaglutide or any ingredient in Wegovy
You have Type 1 diabetes
You suffer from severe digestive conditions, including Crohn’s disease, ulcerative colitis, or gastroparesis
You have advanced kidney or liver disease
You have current gallbladder problems (unless your gallbladder has been removed)
You have diabetic retinopathy (diabetes-related eye complications)You or a close family member have had medullary thyroid cancer (MTC)
You have Multiple Endocrine Neoplasia type 2 (MEN 2)


If any of the above apply, Wegovy® may not be suitable and alternative options should be discussed with a qualified clinician.

 

What to eat when on GLP1 medication?

A key part of your weight loss journey is diet. While weight loss medication will reduce the “food noise”, what you eat and drink is incredibly important. Changing your diet is one of the biggest steps you can take on your weight loss journey.

 

Learn more about a GLP1 Diet Plan

Learn more about GLP1 diet

Citations

[1] Based on a 72 week study, in addition to a reduced-calorie diet and increased physical activity in adults with an obesity (BMI >30 kg/m²). Study was based on patients without type 2 diabetes and using Wegovy 7.2mg (semaglutide).

[2] Based on a study of adults who had a heart attack, store of peripheral arterial disease and also had obesity. Study was based on Wegovy 2.4mg (semaglutide) and their stancard care medicines (e.g blood pressure). On average the adults were on the trial for 3.5 years. Adults are receive healthy lifestlye counseling help.

[3] Semaglutide in obesity without diabetes in the select trial. https://www.nature.com/articles/s41591-024-02996-7

[4] Semaglutide, a Once-Weekly Human GLP-1 Analog, Does Not Reduce the Bioavailability of the Combined Oral Contraceptive, Ethinylestradiol/Levonorgestrel - https://pmc.ncbi.nlm.nih.gov/articles/PMC4418331/

[5] Based on a study over 68 weeks on adults with obesity and moderate knee OA. https://www.nejm.org/doi/10.1056/NEJMoa2403664

Important Safety Information

Wegovy® is not suitable for everyone, and safety is a key part of the prescribing process. It should not be used by people who have a personal or family history of certain thyroid cancers, or by those with specific endocrine conditions. Wegovy must not be used during pregnancy or while breastfeeding.

As with all prescription medicines, side effects can occur. The most commonly reported side effects are related to the digestive system and may include nausea, vomiting, diarrhoea, constipation, or abdominal discomfort. These effects are most common when starting treatment or increasing the dose and often improve as the body adapts.

 

When to Seek Medical Advice Urgently

Although serious side effects are uncommon, urgent medical advice should be sought if you experience severe or persistent abdominal pain, signs of an allergic reaction such as swelling or difficulty breathing, or sudden changes in vision. These symptoms require prompt assessment.

 

Medical Oversight and Prescribing Process

Wegovy® is supplied only following a structured medical consultation that is reviewed by a UK-registered prescriber. This process ensures that the treatment is appropriate, safe, and aligned with current medical guidance.

During treatment, progress may be reviewed and adjustments made if needed. In some cases, treatment may be paused or stopped if it is no longer suitable or if side effects outweigh the benefits.

 

Regulation, Trust, and Patient Safety
As a regulated pharmacy service, prescriptions are issued only when clinically appropriate. There are no automatic approvals, and patient safety is prioritised at every stage. Clear eligibility criteria, medical oversight, and ongoing review are central to how Wegovy treatment is provided.

 

A Balanced, Responsible Approach to Weight Management
Wegovy is one option among several for managing weight. It is not suitable for everyone, and it is not a substitute for healthy lifestyle changes. For those who meet the criteria and are prescribed the medication, it can be a valuable tool in supporting sustainable weight management under medical supervision.

 

FAQs
  • How does Wegovy® Work?

    Wegovy® mimics the action of the natural hormone GLP-1, which regulates appetite and food intake. By acting on specific brain receptors, it helps you feel fuller for longer, reduces hunger, and decreases food cravings. This makes it easier to follow a calorie-controlled diet and maintain weight loss.

  • What are the proven benefits of Wegovy®?

    Clinically proven weight loss – on average, participants lost around 15% of body weight in clinical trials over 68 weeks when combined with diet and exercise.
    Sustained results – benefits maintained for up to two years in long-term studies.
    Heart health protection – a 20% reduction in the risk of heart attack, stroke, or cardiovascular death in high-risk adults, as shown in the select trial.
    Improved cardiometabolic health markers, including lower blood pressure, reduced waist circumference, and improved cholesterol profiles.

  • What are the Wegovy® Dosing & Administration Instructions?

    Starting dose: 0.25 mg once weekly for 4 weeks.
    Gradual dose increase every 4 weeks (0.5 mg → 1.0 mg → 1.7 mg) until reaching the maintenance dose of 2.4 mg once weekly.
    Delivered via the Wegovy® FlexTouch® pre-filled pen for self-injection into the abdomen, thigh, or upper arm.
    Pens are stored refrigerated before opening and can be kept below 30°C for up to 6 weeks after first use.

  • Who Should Not Use Wegovy®?

    Wegovy is not suitable for:

    People under 12 years of age
    Pregnant or breastfeeding women
    Anyone allergic to semaglutide or the listed ingredients
    People using other GLP-1 receptor agonist medications

    Possible Side Effects
    Common side effects include nausea, vomiting, diarrhoea, constipation, and stomach pain, especially during dose escalation. These often lessen over time. Serious but rare side effects can include pancreatitis, gallstones, severe allergic reactions, or bowel obstruction. Always discuss potential risks with your prescriber.


    Why Choose Wegovy® from Shape8
    Private prescription service with full eligibility screening
    Fast, discreet UK delivery
    Ongoing medical support to help you achieve and maintain results
    Guidance on healthy eating and activity plans tailored to your needs

  • What are the Possible Side Effects of Wegovy®

    Common side effects include nausea, vomiting, diarrhoea, constipation, and stomach pain, especially during dose escalation. These often lessen over time. Serious but rare side effects can include pancreatitis, gallstones, severe allergic reactions, or bowel obstruction. Always discuss potential risks with your prescriber.

     

  • What are the Expected Results & Timelines of Wegovy®?

    Wegovy® works gradually, helping you achieve sustainable results rather than rapid, short-term loss. In clinical trials, patients lost on average around 15% of their starting body weight over 68 weeks when combined with a healthy diet and regular physical activity. Many people begin noticing changes in appetite and early weight loss within the first month, with steady progress as the weeks go by.

  • What’s in the Wegovy® Box?

    • 1 pre-filled Wegovy® FlexTouch® pen (containing four weekly doses)
    • 4 disposable needles
    • Patient Information Leaflet with step-by-step instructions

    What is the Wegovy pen

     

    * This image is for illustration purposees only and does not reflect the actual size of the pen.

  • Wegovy® or Mounjaro?

  • What happens if I miss a dose of Wegovy®?

    If your next scheduled dose is more than 48 hours away, take the missed dose as soon as you remember.

    If your next scheduled dose is less than 48 hours away, skip the missed dose and take your next injection on your usual scheduled day.

    If it has been 14 days or more since your last dose, either take your next dose on your regular scheduled day or speak to your healthcare professional for advice on how to restart treatment.

  • How to care for your Wegovy® pen?

    Do not drop the pen or allow it to hit hard surfaces.

    Keep the pen away from liquids and do not expose it to water.

    If you believe the pen may be damaged, do not use it or attempt to repair it. Dispose of it safely and use a new pen.

    To reduce the risk of infection, keep the cap on until you are ready to inject. The pen will no longer be sterile if it is stored without the cap, if the cap has been removed and replaced, or if the cap is missing.

  • How do I use Wegovy®?

    Wegovy® is taken once weekly using the FlexTouch® pen. Always read the Patient Information Leaflet before starting, and speak to your doctor, nurse or pharmacist if you are unsure how to inject correctly.

     
    1. Get started

    • Check the name and dose on the pen to ensure it matches your prescribed strength (0.25 mg, 0.5 mg, 1 mg, 1.7 mg or 2.4 mg).
    • If prescribed 7.2 mg weekly (three injections of 2.4 mg), ensure you have enough 2.4 mg pens available before starting.
    • Remove the pen cap and check the solution through the viewing window. The liquid should be clear and colourless.
    • Do not use the pen if the solution appears cloudy or discoloured.

     

    2. Attach a new needle

    • Always use a new needle for every injection.
    • If taking 7.2 mg (three 2.4 mg injections), use a new needle for each injection.
    • Do not use bent or damaged needles.
    • Remove the paper tab, push the needle straight onto the pen and twist until secure.
    • Remove the outer needle cap and keep it.
    • Remove and safely dispose of the inner needle cap.

     

    3. Check the flow (new pens only)

    Only required before the first injection with each new pen.

    • Turn the dose selector until the flow check symbol aligns with the dose pointer.
    • Hold the pen upright with the needle pointing upwards.
    • Press and hold the dose button until the counter returns to 0.
    • A small drop should appear at the needle tip.


    If no drop appears:

    • Repeat once more.
    • If still no drop, change the needle and try again.
    • Do not use the pen if a drop still does not appear. 

    4. Set the dose

    • If prescribed 7.2 mg weekly (three injections), select 2.4 mg for each injection.
    • Turn the dose selector until the dose counter stops and shows your prescribed dose.
    • When the dose lines up with the dose pointer, it has been correctly selected.
    • Do not set the dose by counting clicks.

     

    5. Choose an injection site and inject

    • Insert the needle into your skin, ensuring the dose counter is visible.
    • Press and hold the dose button until the counter shows 0.
    • Keep the needle in your skin and slowly count to six. The 0 must align with the dose pointer.
    • Remove the needle from your skin.
    • If there is slight bleeding, apply gentle pressure.


    If prescribed 7.2 mg weekly (three 2.4 mg injections):

    • Use a new needle for each injection.
    • If a new pen is required for the second or third injection, repeat steps 1–5.
    • The three injections may be given in the same body area but must be at least 5 cm apart.
    • Do not discard a pen until it is empty.
    • Store partially used pens in the fridge with the needle removed.
    • Ensure you have enough pens to complete your full dose before starting.

     

    6. After injection

    • Carefully guide the needle into the outer needle cap placed on a flat surface.
    • Do not attempt to replace the inner needle cap.
    • Once covered, firmly push the outer cap on and unscrew the needle.
    • Dispose of the needle safely in a sharps container.
    • Replace the pen cap after each use to protect the medication from light.

     

    Where should I inject Where should I inject Wegovy? 

  • Does Wegovy® affect oral contraception?

    Wegovy® is not expected to reduce the effectiveness of oral contraceptives.

    There is no requirement in the Summary of Product Characteristics (SmPC) for women of childbearing age to switch to a non-oral contraceptive method while taking Wegovy®.

  • Can Wegovy® reduce Cardiovascular Risk?

    20% relative risk reduction (1.5% ARR) in MACE*

    Wegovy® is the only weight management medication also approved to reduce cardiovascular risk in adults living with overweight or obesity who have established cardiovascular disease, when used alongside a reduced-calorie diet and increased physical activity.

    Cardiovascular benefit beyond weight loss

    A pre-specified analysis of the SELECT trial found that the reduction in major adverse cardiovascular events (MACE) with Wegovy® was observed regardless of the amount of weight lost at week 20 (both under 5% and 5% or more).

    This suggests that the cardiovascular benefits of Wegovy® may extend beyond weight reduction alone.

     

     

    *  Wegovy® N=8803, placebo N=8801; the patients did not have diabetes. p<0.001.

  • Why does Wegovy® pens come in different colours?

    Wegovy® is available in five dose strengths: 0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg and 2.4 mg.

    Each strength is supplied in a pre-filled pen with a distinct colour to help identify the correct dose.

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Author information

All of our medication and condition content is created by fully qualified UK pharmacists and doctors.

Dr Kamran Amjed
Written by

Dr Kamran Amjed

Clinical Lead
Last Updated Date
Published Date09/03/2026